Bi(OTf)3‑Catalyzed Diastereoselective One-Pot Synthesis of 1,3-Diamines with Three Continuous Stereogenic Centers
A highly modular, diastereoselective one-pot-synthesis of 1,3-diamines with three contiguous stereogenic centers is reported. Our method provides a fast and efficient access to 1,2-anti-2,3-anti-1,3-diamines from three readily available building blocks. This Bi(OTf)3-catalyzed reaction is insensiti...
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| Veröffentlicht in: | Journal of organic chemistry 2018-10, Vol.83 (19), p.12007-12022 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A highly modular, diastereoselective one-pot-synthesis of 1,3-diamines with three contiguous stereogenic centers is reported. Our method provides a fast and efficient access to 1,2-anti-2,3-anti-1,3-diamines from three readily available building blocks. This Bi(OTf)3-catalyzed reaction is insensitive to air and moisture and can be performed on a multigram scale. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.8b01925 |