Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: A double-blind, placebo-controlled study

In the current study, only a small proportion of the patients enrolled had positive skin prick or patch testing results when nonirritating concentrations as determined by a pilot study in healthy adults were applied. [...]positivity showed no significant association with a history of an adverse reaction related to food on the screening questionnaire or DBPC oral challenge outcome. [...]the DBPC oral challenge showed that the difference between the positivity rates to the food additive mixture and placebo was not significant.