Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids
Highlights • Glycosomes in Kinetoplastea are peroxisomes that harbor glycolytic enzymes. • Compartmentation of glycolysis is an alternative to feedback regulation of enzymes. • A glycosome-targeted protein phosphatase conveys a life-stage differentiation signal. • Glycosome turnover allows rapid rem...
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| Veröffentlicht in: | Current opinion in microbiology 2014-12, Vol.22, p.79-87 |
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| container_title | Current opinion in microbiology |
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| creator | Szöör, Balázs Haanstra, Jurgen R Gualdrón-López, Melisa Michels, Paul AM |
| description | Highlights • Glycosomes in Kinetoplastea are peroxisomes that harbor glycolytic enzymes. • Compartmentation of glycolysis is an alternative to feedback regulation of enzymes. • A glycosome-targeted protein phosphatase conveys a life-stage differentiation signal. • Glycosome turnover allows rapid remodelling of metabolism upon changing contexts. • Metabolic adaptability through glycosomes: an advantage in evolution of parasitism? |
| doi_str_mv | 10.1016/j.mib.2014.09.006 |
| format | Article |
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| identifier | ISSN: 1369-5274 |
| ispartof | Current opinion in microbiology, 2014-12, Vol.22, p.79-87 |
| issn | 1369-5274 1879-0364 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | cytosol enzymes evolution glycolysis Kinetoplastea Life Cycle Stages - physiology lifestyle microbiology Microbodies - metabolism Pathology peroxisomes species Trypanosoma brucei Trypanosomatina - genetics Trypanosomatina - growth & development Trypanosomatina - metabolism |
| title | Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids |
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