Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids

Highlights • Glycosomes in Kinetoplastea are peroxisomes that harbor glycolytic enzymes. • Compartmentation of glycolysis is an alternative to feedback regulation of enzymes. • A glycosome-targeted protein phosphatase conveys a life-stage differentiation signal. • Glycosome turnover allows rapid rem...

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Veröffentlicht in:	Current opinion in microbiology 2014-12, Vol.22, p.79-87
Hauptverfasser:	Szöör, Balázs, Haanstra, Jurgen R, Gualdrón-López, Melisa, Michels, Paul AM
Format:	Artikel
Sprache:	eng
Schlagworte:	cytosol enzymes evolution glycolysis Kinetoplastea Life Cycle Stages - physiology lifestyle microbiology Microbodies - metabolism Pathology peroxisomes species Trypanosoma brucei Trypanosomatina - genetics Trypanosomatina - growth & development Trypanosomatina - metabolism
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Zusammenfassung:	Highlights • Glycosomes in Kinetoplastea are peroxisomes that harbor glycolytic enzymes. • Compartmentation of glycolysis is an alternative to feedback regulation of enzymes. • A glycosome-targeted protein phosphatase conveys a life-stage differentiation signal. • Glycosome turnover allows rapid remodelling of metabolism upon changing contexts. • Metabolic adaptability through glycosomes: an advantage in evolution of parasitism?
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2014.09.006