Fabrication of a new superparamagnetic metal-organic framework with core-shell nanocomposite structures: Characterization, biocompatibility, and drug release study

The Superparamagnetic CoFe2O4NPs@Mn-Organic Framework core-shell nanocomposites that had potential application in targeted drug-delivery were synthesized by layer to layer method. The structure and composition of the obtained microspheres were characterized by SEM, TEM, DLS, XRD, VSM, FTIR, and TG analysis. Results showed that the structures have a high degree crystalline, high temperature stability, magnetics and core-shell nanocomposites. Therefore, it is an excellent candidate for drug delivery systems. Afterwards, Daunorubicin (as a drug model) was laden in the MOFs by a Simple stirring. For comparison of magnetic properties of MOFs for drug delivery, an external magnetic field applied to the plate to evaluate the efficiency. The external magnetic field significantly increases anti-tumor activity of formulation (drug+ MOFs). The results showed that MOFs are biocompatible, which endue MOFs great potential in targeting drug-delivery systems with enhanced efficiency. •Facile synthesis of CoFe2O4NPs by the co-precipitation Method•The Superparamagnetic CoFe2O4NPs@Mn-Organic Framework core-shell nanocomposite was fabricated using a simple and fast method.•CoFe2O4 nanoparticles exhibited superparamagnetic behavior with moderate saturation magnetization and hydrophilic character.•A new magnetic drug carrier for targeted drug delivery.•The drug loading capacity was high and the drug release behavior was sufficient, which endue MOFs great potential in targeting drug-delivery systems with enhanced efficiency.