Continuous‐Flow Suzuki‐Miyaura and Mizoroki‐Heck Reactions under Microwave Heating Conditions

Microwave‐assisted continuous‐flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large‐scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki‐Miyaura and Mizoroki‐Heck reactions, both of which are significantly important cross‐coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl2(PPh3)2, Pd(PPh3)4, and Pd(OAc)2, as well as heterogeneous palladium catalysts, such as Pd‐film, Pd/Al2O3, Pd/SiO2, and Pd supported on polymers, can be used for these reactions. Recent progress on the microwave‐assisted continuous‐flow Suzuki‐Miyaura and Mizoroki‐Heck reactions is demonstrated based on the classification of homogeneous and heterogeneous palladium catalysts.