Chronic lymphocytic leukemia patients with heterogeneously or fully methylated LPL promotor display longer time to treatment

We investigated whether DNA methylation regulates expression of LPL and PI3K complex genes in chronic lymphocytic leukemia (CLL) and evaluated the prognostic significance of LPL promoter methylation in CLL patients. Patients & methods: Methylation of LPL promoter was assessed in 112 patients usi...

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Veröffentlicht in:	Epigenomics 2018-09, Vol.10 (9), p.1155-1166
Hauptverfasser:	Daugaard, Iben, Hussmann, Dianna, Kristensen, Louise, Kristensen, Thomas, Kjeldsen, Tina E, Nyvold, Charlotte G, Larsen, Thomas S, Møller, Michael B, Hansen, Lise Lotte, Wojdacz, Tomasz K
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Biomarkers Cancer Chronic lymphocytic leukemia Deoxyribonucleic acid DNA DNA methylation Gene expression Genomes Leukemia Lipoprotein lipase Lipoproteins Lymphatic leukemia Medical prognosis Metabolism Mutation Patients
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Zusammenfassung:	We investigated whether DNA methylation regulates expression of LPL and PI3K complex genes in chronic lymphocytic leukemia (CLL) and evaluated the prognostic significance of LPL promoter methylation in CLL patients. Patients & methods: Methylation of LPL promoter was assessed in 112 patients using methylation-sensitive high-resolution melting (MS-HRM). Patients with a fully or heterogeneously methylated LPL promoter had significantly longer median time to treatment (p
ISSN:	1750-1911 1750-192X
DOI:	10.2217/epi-2018-0020