X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and ind...
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| Veröffentlicht in: | Radiotherapy and oncology 2018-12, Vol.129 (3), p.582-588 |
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| container_end_page | 588 |
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| container_title | Radiotherapy and oncology |
| container_volume | 129 |
| creator | Montay-Gruel, Pierre Bouchet, Audrey Jaccard, Maud Patin, David Serduc, Raphael Aim, Warren Petersson, Kristoffer Petit, Benoit Bailat, Claude Bourhis, Jean Bräuer-Krisch, Elke Vozenin, Marie-Catherine |
| description | This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis. |
| doi_str_mv | 10.1016/j.radonc.2018.08.016 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0167-8140 |
| ispartof | Radiotherapy and oncology, 2018-12, Vol.129 (3), p.582-588 |
| issn | 0167-8140 1879-0887 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Cognitive impairment Radiation-induced brain injury Synchrotron radiation Ultra-high dose-rate X-ray radiation |
| title | X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice |
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