X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and ind...

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Veröffentlicht in:Radiotherapy and oncology 2018-12, Vol.129 (3), p.582-588
Hauptverfasser: Montay-Gruel, Pierre, Bouchet, Audrey, Jaccard, Maud, Patin, David, Serduc, Raphael, Aim, Warren, Petersson, Kristoffer, Petit, Benoit, Bailat, Claude, Bourhis, Jean, Bräuer-Krisch, Elke, Vozenin, Marie-Catherine
Format: Artikel
Sprache:eng
Schlagworte:
Cognitive impairment
Radiation-induced brain injury
Synchrotron radiation
Ultra-high dose-rate X-ray radiation
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Zusammenfassung:This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2018.08.016