Impact of dose and duration of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B

Background Systemic corticosteroid is used for different medical conditions and may cause hepatitis B virus (HBV) reactivation. Aims To study the impact of duration and peak dose of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B (CHB). Methods All patients who rec...

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Veröffentlicht in:Liver international 2019-02, Vol.39 (2), p.271-279
Hauptverfasser: Wong, Grace Lai‐Hung, Yuen, Becky Wing‐Yan, Chan, Henry Lik‐Yuen, Tse, Yee‐Kit, Yip, Terry Cheuk‐Fung, Lam, Kelvin Long‐Yan, Lui, Grace Chung‐Yan, Wong, Vincent Wai‐Sun, Negro, Francesco
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Sprache:eng
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Zusammenfassung:Background Systemic corticosteroid is used for different medical conditions and may cause hepatitis B virus (HBV) reactivation. Aims To study the impact of duration and peak dose of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B (CHB). Methods All patients who received corticosteroid from January 2001 to December 2004 were retrieved from the Hospital Authority, Hong Kong. We stratified patients by daily dose prednisolone equivalents (40 mg) and durations (28 days). The primary endpoint was hepatitis flare (alanine aminotransferase >2×upper limit of normal, ie 80 IU/L) at 1 year. Results A total of 85 763 patients fulfilled the inclusion criteria (5254 CHB, 80 509 non‐CHB). CHB patients had higher risk of hepatitis flare (388/5254 [7.8%]) than those without CHB (2728/80 509 [4.2%]; P 40 mg compared to
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13953