Clinical and pathological features of idiopathic membranous nephropathy in young people

ABSTRACT Aim To investigate the clinico‐pathological features of idiopathic membranous nephropathy (IMN) in youth. Methods Patients with biopsy‐proven IMN in Peking University Third Hospital from May 2015 to October 2017 (n = 147) were enrolled in this study. Patients were divided into youth (≤35 ye...

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Veröffentlicht in:	Nephrology (Carlton, Vic.) Vic.), 2019-06, Vol.24 (6), p.599-604
Hauptverfasser:	Lin, Chu, Zheng, Danxia, Wang, Yue, Wang, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age Factors Aged Autoantibodies - blood Biopsy Complement C3 - immunology Disease Progression Female Geriatrics Glomerulonephritis, Membranous - drug therapy Glomerulonephritis, Membranous - immunology Glomerulonephritis, Membranous - pathology Glomerulonephritis, Membranous - physiopathology Humans idiopathic membranous nephropathy Immunosuppressive Agents - therapeutic use Kidney diseases Kidney Glomerulus - drug effects Kidney Glomerulus - immunology Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology M type phospholipase A2 receptor Male Medical records Membranous nephropathy Middle Aged Nephropathy nephrotic syndrome Patients Phospholipase A2 Proteinuria Receptors, Phospholipase A2 - immunology Remission Remission Induction Retrospective Studies Severity of Illness Index Time Factors Treatment Outcome
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Zusammenfassung:	ABSTRACT Aim To investigate the clinico‐pathological features of idiopathic membranous nephropathy (IMN) in youth. Methods Patients with biopsy‐proven IMN in Peking University Third Hospital from May 2015 to October 2017 (n = 147) were enrolled in this study. Patients were divided into youth (≤35 years old), middle‐age (35–65 years old) and elderly group (>65 years old) accordingly. Medical records of patients were retrospectively analyzed. Results Youth group exhibited shorter duration from onset to biopsy (3.49 ± 4.25 months in youth vs 8.71 ± 12.24 months in elderly) and milder clinical presentations in terms of less proteinuria and higher serum albumin (P
ISSN:	1320-5358 1440-1797
DOI:	10.1111/nep.13486