HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels

Abstract Summary HLA allele imputation from SNP genotypes has become increasingly useful, but its accuracy is heavily dependent on the reference panels used. HLA-IMPUTER implements HIBAG algorithm for HLA imputation with different population specific reference panels, including a new Han Chinese ref...

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Veröffentlicht in:	Bioinformatics 2019-04, Vol.35 (7), p.1244-1246
Hauptverfasser:	Shen, Jiangshan J, Yang, Chao, Wang, Yong-Fei, Wang, Ting-You, Guo, Mengbiao, Lau, Yu Lung, Zhang, Xuejun, Sheng, Yujun, Yang, Wanling
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Asian Continental Ancestry Group Genome-Wide Association Study Genotype HLA Antigens Humans Polymorphism, Single Nucleotide Software
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Zusammenfassung:	Abstract Summary HLA allele imputation from SNP genotypes has become increasingly useful, but its accuracy is heavily dependent on the reference panels used. HLA-IMPUTER implements HIBAG algorithm for HLA imputation with different population specific reference panels, including a new Han Chinese reference panel derived from 10 689 samples. We provide a convenient platform for researchers to impute HLA alleles and perform association analysis. Availability and implementation http://wyanglab.org: 3838/RefPanelWebsite/. Supplementary information Supplementary data are available at Bioinformatics online.
ISSN:	1367-4803 1460-2059 1367-4811
DOI:	10.1093/bioinformatics/bty730