Optimizing Tacrolimus Therapy in the Maintenance of Renal Allografts : 12-Month Results

The determination of optimal tacrolimus (TAC) trough levels is needed to prevent adverse effects of calcineurin inhibitors. Stable transplant recipients currently receiving cyclosporine (CsA) were assigned randomly (1:1:1) to continue CsA (target trough level of 50-250 ng/mL); or convert to "re...

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Veröffentlicht in:	Transplantation 2008-07, Vol.86 (1), p.88-95
Hauptverfasser:	BOLIN, Paul, SHIHAB, Fuad S, MULLOY, Laura, HENNING, Alice K, GAO, Jeff, BARTUCCI, Marilyn, HOLMAN, John, FIRST, M. Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cardiovascular Diseases - etiology Cyclosporine - administration & dosage Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - metabolism Graft Rejection - physiopathology Graft Rejection - prevention & control Graft Survival - drug effects Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - blood Kidney Function Tests Kidney Transplantation Lipids - blood Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Quality of Life Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - administration & dosage Tacrolimus - adverse effects Tacrolimus - blood Time Factors Tissue, organ and graft immunology Treatment Outcome United States
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Zusammenfassung:	The determination of optimal tacrolimus (TAC) trough levels is needed to prevent adverse effects of calcineurin inhibitors. Stable transplant recipients currently receiving cyclosporine (CsA) were assigned randomly (1:1:1) to continue CsA (target trough level of 50-250 ng/mL); or convert to "reduced" TAC (target trough level 3.0-5.9 ng/mL) or "standard" TAC (target trough level 6.0-8.9 ng/mL). At 12 months, there was a significant improvement in renal function in the reduced TAC versus CsA group with lower serum creatinine (P=0.004) and cystatin C (P
ISSN:	0041-1337 1534-6080
DOI:	10.1097/tp.0b013e31817442cf