Insights into Proteasome Conformation Dynamics and Intersubunit Communication

Insights into Proteasome Conformation Dynamics and Intersubunit Communication

A recently published paper applies cryo-electron microscopy (EM) studies and biochemical/genetic approaches for the elucidation of the mechanisms linking nucleotide binding by ATPases, proteasome conformation dynamics, and gate opening of the 20S core particle. These insights potentially represent a...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2018-11, Vol.43 (11), p.852-853
Hauptverfasser: Tundo, Grazia R., Sbardella, Diego, Coletta, Massimo
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphatases
allosteric interactions
ATPase cycle
conformation dynamics
core particles-regulatory particles interaction
Cryoelectron Microscopy
Molecular Conformation
proteasome assembly
Proteasome Endopeptidase Complex
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Zusammenfassung:A recently published paper applies cryo-electron microscopy (EM) studies and biochemical/genetic approaches for the elucidation of the mechanisms linking nucleotide binding by ATPases, proteasome conformation dynamics, and gate opening of the 20S core particle. These insights potentially represent a milestone in our understanding of the structural dynamics of the 26S proteasome.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2018.08.002