Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension

A systematic review and meta-analysis was performed to test candidate therapeutic approaches in pulmonary hypertension (PH). The efficacy of 522 interventions with >200 unregistered drugs was tested on 7254 animals. We propose a modified formula to assess meta-data that concerns the contribution...

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Veröffentlicht in:	Vascular pharmacology 2018-11, Vol.110, p.55-63
Hauptverfasser:	Sztuka, Katarzyna, Orszulak-Michalak, Daria, Jasińska-Stroschein, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animal Animal models Animals Blood pressure Effectiveness Eutrophication Fatty acids Hypertension Hypertrophy Inhibitors Meta-analysis Novel strategies Parameter sensitivity Polyunsaturated fatty acids Potassium Pulmonary artery Pulmonary hypertension Regulators Review Systematic Systematic review Systolic pressure Ventricle Wall thickness
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Beschreibung
Zusammenfassung:	A systematic review and meta-analysis was performed to test candidate therapeutic approaches in pulmonary hypertension (PH). The efficacy of 522 interventions with >200 unregistered drugs was tested on 7254 animals. We propose a modified formula to assess meta-data that concerns the contribution of PH animal model to the denoted efficacy of tested agents. The measure of efficacy expressed as a response ratio for right ventricle systolic pressure was 0.48 (95% CI, 0.46–0.50; P
ISSN:	1537-1891 1879-3649
DOI:	10.1016/j.vph.2018.08.004