Targeted Therapies in the Treatment of Sarcomas

Targeted Therapies in the Treatment of Sarcomas

About 50% of sarcomas have specific pathology-defining molecular alterations including mutations, fusion genes, and gene amplifications. Some of these alterations appear to be oncogenic drivers, and a subset can be utilized as targets for standard or experimental molecularly targeted agents in the c...

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Veröffentlicht in:Targeted oncology 2018-10, Vol.13 (5), p.557-565
Hauptverfasser: Hoffner, Brianna, Elias, Anthony D., Villalobos, Victor M.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedicine
Medicine
Medicine & Public Health
Oncology
Review Article
Sarcoma
Targeted cancer therapy
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Zusammenfassung:About 50% of sarcomas have specific pathology-defining molecular alterations including mutations, fusion genes, and gene amplifications. Some of these alterations appear to be oncogenic drivers, and a subset can be utilized as targets for standard or experimental molecularly targeted agents in the clinic. In addition, immunotherapies may have a growing role in the treatment of sarcomas in the future.
ISSN:1776-2596
1776-260X
DOI:10.1007/s11523-018-0583-0