Identification of the toxic trigger in mushroom poisoning
We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans . This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase ac...
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| Veröffentlicht in: | Nature chemical biology 2009-07, Vol.5 (7), p.465-467 |
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| creator | Matsuura, Masanori Saikawa, Yoko Inui, Kosei Nakae, Koichi Igarashi, Masayuki Hashimoto, Kimiko Nakata, Masaya |
| description | We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom
Russula subnigricans
. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity. |
| doi_str_mv | 10.1038/nchembio.179 |
| format | Article |
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Russula subnigricans
. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.</description><identifier>ISSN: 1552-4450</identifier><identifier>EISSN: 1552-4469</identifier><identifier>DOI: 10.1038/nchembio.179</identifier><identifier>PMID: 19465932</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agaricales - chemistry ; Animals ; Biochemical Engineering ; Biochemistry ; Bioorganic Chemistry ; brief-communication ; Carboxylic acids ; Carboxylic Acids - chemical synthesis ; Carboxylic Acids - isolation & purification ; Carboxylic Acids - toxicity ; Cell Biology ; Cell Line, Tumor ; Chemical compounds ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Cyclopropanes - chemical synthesis ; Cyclopropanes - isolation & purification ; Cyclopropanes - toxicity ; Lethal Dose 50 ; Magnetic Resonance Spectroscopy ; Mice ; Mice, Inbred ICR ; Molecular Structure ; Mushroom Poisoning - etiology ; Mushrooms ; Mycotoxins - chemical synthesis ; Mycotoxins - isolation & purification ; Mycotoxins - toxicity ; Poisoning ; Rhabdomyolysis - etiology ; Russula ; Toxins</subject><ispartof>Nature chemical biology, 2009-07, Vol.5 (7), p.465-467</ispartof><rights>Springer Nature America, Inc. 2009</rights><rights>Copyright Nature Publishing Group Jul 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f58f107a8d8740331339c77b3a3cb5fd1a0fc082c76ff3f4ef152b8b3ccb6e313</citedby><cites>FETCH-LOGICAL-c452t-f58f107a8d8740331339c77b3a3cb5fd1a0fc082c76ff3f4ef152b8b3ccb6e313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nchembio.179$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nchembio.179$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19465932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuura, Masanori</creatorcontrib><creatorcontrib>Saikawa, Yoko</creatorcontrib><creatorcontrib>Inui, Kosei</creatorcontrib><creatorcontrib>Nakae, Koichi</creatorcontrib><creatorcontrib>Igarashi, Masayuki</creatorcontrib><creatorcontrib>Hashimoto, Kimiko</creatorcontrib><creatorcontrib>Nakata, Masaya</creatorcontrib><title>Identification of the toxic trigger in mushroom poisoning</title><title>Nature chemical biology</title><addtitle>Nat Chem Biol</addtitle><addtitle>Nat Chem Biol</addtitle><description>We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom
Russula subnigricans
. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.</description><subject>Agaricales - chemistry</subject><subject>Animals</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Bioorganic Chemistry</subject><subject>brief-communication</subject><subject>Carboxylic acids</subject><subject>Carboxylic Acids - chemical synthesis</subject><subject>Carboxylic Acids - isolation & purification</subject><subject>Carboxylic Acids - toxicity</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Cyclopropanes - chemical synthesis</subject><subject>Cyclopropanes - isolation & purification</subject><subject>Cyclopropanes - toxicity</subject><subject>Lethal Dose 50</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Structure</subject><subject>Mushroom Poisoning - 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Russula subnigricans
. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>19465932</pmid><doi>10.1038/nchembio.179</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature chemical biology, 2009-07, Vol.5 (7), p.465-467 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Agaricales - chemistry Animals Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Carboxylic acids Carboxylic Acids - chemical synthesis Carboxylic Acids - isolation & purification Carboxylic Acids - toxicity Cell Biology Cell Line, Tumor Chemical compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclopropanes - chemical synthesis Cyclopropanes - isolation & purification Cyclopropanes - toxicity Lethal Dose 50 Magnetic Resonance Spectroscopy Mice Mice, Inbred ICR Molecular Structure Mushroom Poisoning - etiology Mushrooms Mycotoxins - chemical synthesis Mycotoxins - isolation & purification Mycotoxins - toxicity Poisoning Rhabdomyolysis - etiology Russula Toxins |
| title | Identification of the toxic trigger in mushroom poisoning |
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