Identification of the toxic trigger in mushroom poisoning

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans . This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase ac...

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Veröffentlicht in:	Nature chemical biology 2009-07, Vol.5 (7), p.465-467
Hauptverfasser:	Matsuura, Masanori, Saikawa, Yoko, Inui, Kosei, Nakae, Koichi, Igarashi, Masayuki, Hashimoto, Kimiko, Nakata, Masaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Animals Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Carboxylic acids Carboxylic Acids - chemical synthesis Carboxylic Acids - isolation & purification Carboxylic Acids - toxicity Cell Biology Cell Line, Tumor Chemical compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclopropanes - chemical synthesis Cyclopropanes - isolation & purification Cyclopropanes - toxicity Lethal Dose 50 Magnetic Resonance Spectroscopy Mice Mice, Inbred ICR Molecular Structure Mushroom Poisoning - etiology Mushrooms Mycotoxins - chemical synthesis Mycotoxins - isolation & purification Mycotoxins - toxicity Poisoning Rhabdomyolysis - etiology Russula Toxins
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Zusammenfassung:	We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans . This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.179