Sex bias in autism: new insights from Chd8 mutant mice?

A study has found that young male mice with a mutation of the autism-associated gene Chd8 show abnormal behaviors and elevated neuronal activation in several brain areas under stressful conditions, while female mice with the same mutation have reduced baseline neuronal activity, which may protect th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2018-09, Vol.21 (9), p.1144-1146
Hauptverfasser:	Andreae, Laura C., Basson, M. Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14 38 38/91 45 631/378/1689/1373 64 64/60 692/699/476/1373 Animal Genetics and Genomics Animals Autism Autistic Disorder Behavioral Sciences Bias Biological Techniques Biomedical and Life Sciences Biomedicine Brain DNA-Binding Proteins - genetics Gene Expression Gene mutation Genes Genetic aspects Genetic research Genotypes Health aspects Mice Mutation Neural circuitry Neurobiology Neurons Neurophysiology Neurosciences News & Views news-and-views Phenotypes Risk factors Rodents Scientists Sex differences (Biology) Sex discrimination Sexism Transcription Factors - genetics Universities and colleges
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A study has found that young male mice with a mutation of the autism-associated gene Chd8 show abnormal behaviors and elevated neuronal activation in several brain areas under stressful conditions, while female mice with the same mutation have reduced baseline neuronal activity, which may protect them from developing these abnormal phenotypes.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/s41593-018-0217-y