Alzheimer’s Disease in 22 Twin Pairs – 13-Year Follow-Up: Hormonal, Infectious and Traumatic Factors
We obtained follow-up data on 22 sets of twins where at least one twin had Alzheimer’s disease (AD). The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterect...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 1999-03, Vol.10 (2), p.148-151 |
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| container_title | Dementia and geriatric cognitive disorders |
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| creator | Nee, Linda E. Lippa, Carol F. |
| description | We obtained follow-up data on 22 sets of twins where at least one twin had Alzheimer’s disease (AD). The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterectomies also had a tendency to develop AD at an earlier age than their co-twin. Five twins with serious systemic infection developed AD, and they tended to have earlier onset than their corresponding twin. We found no strong evidence that head injury predisposed to AD. |
| doi_str_mv | 10.1159/000017115 |
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The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterectomies also had a tendency to develop AD at an earlier age than their co-twin. Five twins with serious systemic infection developed AD, and they tended to have earlier onset than their corresponding twin. We found no strong evidence that head injury predisposed to AD.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000017115</identifier><identifier>PMID: 10026389</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - epidemiology ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Biological and medical sciences ; Craniocerebral Trauma - complications ; Craniocerebral Trauma - epidemiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterectomies also had a tendency to develop AD at an earlier age than their co-twin. Five twins with serious systemic infection developed AD, and they tended to have earlier onset than their corresponding twin. We found no strong evidence that head injury predisposed to AD.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Craniocerebral Trauma - complications</subject><subject>Craniocerebral Trauma - epidemiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Estrogen Replacement Therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hormones - physiology</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Infection - complications</subject><subject>Infection - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Original Research Article</subject><subject>Risk Factors</subject><issn>1420-8008</issn><issn>1421-9824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c1qFTEUAOAgiq3VhWtBgoggOJqfSSbHXWl7baGii9uFq-FMJmNTZya3yQxFV30HV75en8S099KKCGZzDuTj_HAIecrZW84VvGP58Sqn98g2LwUvwIjy_k3OCsOY2SKPUjrLqlIaHpItzpjQ0sA2Od3tf5w6P7h4dfkr0X2fHCZH_UiFoMuLHD-jj4leXf6kXBZfHEa6CH0fLoqT1Xt6GOIQRuzf0KOxc3byYU4Ux5YuI84DTt7SBdopxPSYPOiwT-7JJu6Qk8XBcu-wOP704Whv97iwJVdToaQ0rRRCKSdAoZS8k9BwBFFWBpqu0bzStnMCoRTQVFDJtuIo4Xo5DSB3yKt13VUM57NLUz34ZF3f4-jycLUGZQyU5X-hYMC5FFWGL_6CZ2GOeelspFC5reYZvV4jG0NK0XX1KvoB4_eas_r6SPXtkbJ9vik4N4Nr_5Drq2TwcgMwWey7iKP16c5po7Up7wb7hvGri7f_-wcfbxrVq7bL6Nk_0XqU32slqo4</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Nee, Linda E.</creator><creator>Lippa, Carol F.</creator><general>Karger</general><general>S. 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Leukodystrophies. Prion diseases</topic><topic>Estrogen Replacement Therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hormones - physiology</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Infection - complications</topic><topic>Infection - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Original Research Article</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nee, Linda E.</creatorcontrib><creatorcontrib>Lippa, Carol F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nee, Linda E.</au><au>Lippa, Carol F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alzheimer’s Disease in 22 Twin Pairs – 13-Year Follow-Up: Hormonal, Infectious and Traumatic Factors</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>10</volume><issue>2</issue><spage>148</spage><epage>151</epage><pages>148-151</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>We obtained follow-up data on 22 sets of twins where at least one twin had Alzheimer’s disease (AD). The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterectomies also had a tendency to develop AD at an earlier age than their co-twin. Five twins with serious systemic infection developed AD, and they tended to have earlier onset than their corresponding twin. We found no strong evidence that head injury predisposed to AD.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10026389</pmid><doi>10.1159/000017115</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1420-8008 |
| ispartof | Dementia and geriatric cognitive disorders, 1999-03, Vol.10 (2), p.148-151 |
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| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Age of Onset Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - epidemiology Alzheimer Disease - physiopathology Alzheimer Disease - psychology Biological and medical sciences Craniocerebral Trauma - complications Craniocerebral Trauma - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Estrogen Replacement Therapy Female Follow-Up Studies Hormones - physiology Humans Hysterectomy Infection - complications Infection - epidemiology Male Medical sciences Middle Aged Neurology Original Research Article Risk Factors |
| title | Alzheimer’s Disease in 22 Twin Pairs – 13-Year Follow-Up: Hormonal, Infectious and Traumatic Factors |
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