Alzheimer’s Disease in 22 Twin Pairs – 13-Year Follow-Up: Hormonal, Infectious and Traumatic Factors

We obtained follow-up data on 22 sets of twins where at least one twin had Alzheimer’s disease (AD). The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterect...

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Veröffentlicht in:	Dementia and geriatric cognitive disorders 1999-03, Vol.10 (2), p.148-151
Hauptverfasser:	Nee, Linda E., Lippa, Carol F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - epidemiology Alzheimer Disease - physiopathology Alzheimer Disease - psychology Biological and medical sciences Craniocerebral Trauma - complications Craniocerebral Trauma - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Estrogen Replacement Therapy Female Follow-Up Studies Hormones - physiology Humans Hysterectomy Infection - complications Infection - epidemiology Male Medical sciences Middle Aged Neurology Original Research Article Risk Factors
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Zusammenfassung:	We obtained follow-up data on 22 sets of twins where at least one twin had Alzheimer’s disease (AD). The concordance rate for monozygotic twins (n = 17 pairs) was 59%, whereas that for dizygotic twins was 40%. In our series 8 monozygotic twins had hysterectomies; all had AD. The twins with hysterectomies also had a tendency to develop AD at an earlier age than their co-twin. Five twins with serious systemic infection developed AD, and they tended to have earlier onset than their corresponding twin. We found no strong evidence that head injury predisposed to AD.
ISSN:	1420-8008 1421-9824
DOI:	10.1159/000017115