Effects of Paroxetine on Heart Period Variability in Patients with Panic Disorder: A Study of Holter ECG Records

We investigated cardiac autonomic function in 16 patients with panic disorder before and after treatment with paroxetine using Holter ECG records. Our previous data suggest a relative increase in sympathetic activity in patients with panic disorder, especially during sleep. Data for 20 h and awake a...

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Veröffentlicht in:	Neuropsychobiology 1999-01, Vol.40 (3), p.124-128
Hauptverfasser:	Yeragani, Vikram K., Jampala, V.C., Sobelewski, Edward, Kay, Jerald, Igel, Gina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Biological PsychiatryOriginal Paper Electrocardiography, Ambulatory - drug effects Female Fractals Heart Rate - drug effects Humans Male Medical sciences Panic disorder Panic Disorder - drug therapy Panic Disorder - physiopathology Paroxetine - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin Uptake Inhibitors - therapeutic use
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Beschreibung
Zusammenfassung:	We investigated cardiac autonomic function in 16 patients with panic disorder before and after treatment with paroxetine using Holter ECG records. Our previous data suggest a relative increase in sympathetic activity in patients with panic disorder, especially during sleep. Data for 20 h and awake and sleep periods were analyzed using spectral analysis to quantify absolute and relative heart period variability in ultra low (ULF:
ISSN:	0302-282X 1423-0224
DOI:	10.1159/000026608