Urolithiasis in HIV-Positive Patients Treated with Atazanavir

Urolithiasis in HIV-Positive Patients Treated with Atazanavir

Among protease inhibitors, atazanavir has not been associated with urolithiasis in clinical studies. We describe 11 cases of atazanavir-associated urolithiasis in patients with human immunodeficiency virus (HIV) infection. Patients with low water intake, high urinary pH, and a prior history of urina...

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Veröffentlicht in:Clinical infectious diseases 2007-10, Vol.45 (8), p.e105-e108
Hauptverfasser: Couzigou, Carine, Daudon, Michel, Meynard, Jean Luc, Lebas, Françoise Borsa, Higueret, Denise, Escaut, Lélia, Zucman, David, Liotier, Jean-Yves, Quencez, Jean-Louis, Asselah, Karine, May, Thierry, Neau, Didier, Vittecoq, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Atazanavir Sulfate
Female
HIV Infections - complications
HIV Infections - drug therapy
HIV Protease Inhibitors - adverse effects
HIV Protease Inhibitors - therapeutic use
Human immunodeficiency virus
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Oligopeptides - adverse effects
Oligopeptides - therapeutic use
Pyridines - adverse effects
Pyridines - therapeutic use
Risk Factors
Urine - chemistry
Urolithiasis - chemically induced
Water - metabolism
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Zusammenfassung:Among protease inhibitors, atazanavir has not been associated with urolithiasis in clinical studies. We describe 11 cases of atazanavir-associated urolithiasis in patients with human immunodeficiency virus (HIV) infection. Patients with low water intake, high urinary pH, and a prior history of urinary stones may have a higher risk of atazanavir-associated urine crystallization.
ISSN:1058-4838
1537-6591
DOI:10.1086/521930