Long non-coding RNA activated by TGF-β expression in cancer prognosis: A meta-analysis

Long non-coding RNA activated by TGF-β expression in cancer prognosis: A meta-analysis

Recently, long non-coding RNA activated by transforming growth factor beta (TGF-β) (lncRNA ATB) was shown to be useful in cancer prognosis, however, its prognostic value in human cancer has been inconsistent. Our study aimed to explore the prognostic role of lncRNA ATB expression in cancer prognosis...

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Veröffentlicht in:International journal of surgery (London, England) England), 2018-10, Vol.58, p.37-45
Hauptverfasser: Shen, Xionghu, Piao, Longzhen, Zhang, Songnan, Cui, Yan, Cui, Yuzhen, Quan, Xianglan, Sun, Honghua
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Clinicopathologic parameters
Female
Humans
LncRNA ATB
Lymphatic Metastasis
Meta-analysis
Neoplasms - genetics
Neoplasms - mortality
Neoplasms - pathology
Overall survival
Prognosis
RNA, Long Noncoding - analysis
RNA, Long Noncoding - physiology
Transforming Growth Factor beta - physiology
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Zusammenfassung:Recently, long non-coding RNA activated by transforming growth factor beta (TGF-β) (lncRNA ATB) was shown to be useful in cancer prognosis, however, its prognostic value in human cancer has been inconsistent. Our study aimed to explore the prognostic role of lncRNA ATB expression in cancer prognosis. PubMed, Embase, and Cochrane Library databases were thoroughly searched to retrieve studies focusing on the prognostic role of lncRNA ATB expression in cancer, and meta-analysis was performed. A total of 15 studies were included into this meta-analysis. High lncRNA ATB expression was significantly related to shorter overall survival (OS) (HR = 2.44, 95%CI = 1.98–3.01, P 
ISSN:1743-9191
1743-9159
DOI:10.1016/j.ijsu.2018.08.004