Lathyrane‐Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Bioactivity‐guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane‐type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D‐NMR and HR‐ESI‐MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS‐induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.