Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial
Background Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD). Purpose The aim of this study was to evaluate the clinical and radiographic outcomes of reg...
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| Veröffentlicht in: | Clinical implant dentistry and related research 2018-10, Vol.20 (5), p.703-712 |
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| creator | Isler, Sila Cagri Soysal, Fatma Ceyhanlı, Tugce Bakırarar, Batuhan Unsal, Berrin |
| description | Background
Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD).
Purpose
The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri‐implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12‐month follow‐up.
Materials and Methods
Fifty two patients, who had at least one peri‐implantitis lesion was treated by using a bone substitute in combination with CGF or CM. After surgical procedures, implants were allowed for submerged healing. Clinical assessments were conducted at baseline, 6 and 12 months postoperatively, while radiographic evaluation was performed at baseline and 12 months.
Results
Significant reductions were obtained in the mean gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession (MR) values at both 6 and 12 months postoperatively compared to baseline for both treatment procedures (P |
| doi_str_mv | 10.1111/cid.12661 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2089855517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2117760288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-c43e17f518e8afa895425759746b0a5972edb130113b0ea2b038ea5b018fdd433</originalsourceid><addsrcrecordid>eNp1kUtuFDEQhi0EIg9YcAFkiQ1ZdOLHuNvNLhpekSIhIVhbbnf1xFHbHmx3orDiCByA03ESKszAAglvbJU-f6qqn5BnnJ1yPGfOj6dctC1_QA55x3SjBdMP8a2EbJju-wNyVMo1Y4Lzlj8mB5JxrlXbH5IfH2EDEbKt_gZoWfLGOzvTmsHWALHSNNEtZP_z23cftrON1Vdf6FJ83FDw9QoytdSlebbooQHCkG0EmjIWo0MDqmGkm5xu6xWdrKspv6LnlAtUhhSxiB_GFPxXxNzs474Bb-cn5NFk5wJP9_cx-fz2zaf1--byw7uL9fll46SSvHErCbybFNeg7WR1r1ZCdarvVu3ALN4CxoHfzywHBlYMTGqwamBcT-O4kvKYvNx5tzl9WaBUE3xxgDNFSEsxuM1eK6V4h-iLf9DrtOSI3Rlcbte1TGiN1MmOcjmVkmEy2-yDzXeGM3MfmcHIzO_IkH2-Ny5DgPEv-ScjBM52wK2f4e7_JrO-eL1T_gJQdqOo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2117760288</pqid></control><display><type>article</type><title>Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Isler, Sila Cagri ; Soysal, Fatma ; Ceyhanlı, Tugce ; Bakırarar, Batuhan ; Unsal, Berrin</creator><creatorcontrib>Isler, Sila Cagri ; Soysal, Fatma ; Ceyhanlı, Tugce ; Bakırarar, Batuhan ; Unsal, Berrin</creatorcontrib><description>Background
Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD).
Purpose
The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri‐implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12‐month follow‐up.
Materials and Methods
Fifty two patients, who had at least one peri‐implantitis lesion was treated by using a bone substitute in combination with CGF or CM. After surgical procedures, implants were allowed for submerged healing. Clinical assessments were conducted at baseline, 6 and 12 months postoperatively, while radiographic evaluation was performed at baseline and 12 months.
Results
Significant reductions were obtained in the mean gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession (MR) values at both 6 and 12 months postoperatively compared to baseline for both treatment procedures (P < 0.05). At 6 months, no statistically significant difference was observed for all clinical parameters between the groups, whereas the mean PD, CAL and vertical defect depth (VDD) values were statistically significant in favor of the CM group at 12 months (P < 0.05). The mean defect fill (DF) in the CM group (1.99 ±0.76) was not statistically significantly different from that observed in the CCF group (1.63 ±1.00) (P = 0.154).
Conclusions
The outcomes of the present study suggest that both regenerative approaches yielded significant improvements in both clinical and radiographic assessments. The procedure using a collagen membrane in combination with a bone substitute showed better results at 12 months in RST of peri‐implantitis.</description><identifier>ISSN: 1523-0899</identifier><identifier>EISSN: 1708-8208</identifier><identifier>DOI: 10.1111/cid.12661</identifier><identifier>PMID: 30118569</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Assessments ; barrier membranes ; Biocompatibility ; Biomedical materials ; Bleeding ; Bone biomaterials ; Bone growth ; Bone implants ; Bone Substitutes - therapeutic use ; Clinical trials ; Collagen ; Collagen - therapeutic use ; concentrated growth factor ; Dentistry ; Female ; Gingival index ; Growth factors ; guided bone regeneration ; Humans ; Intercellular Signaling Peptides and Proteins - therapeutic use ; Male ; Membranes ; Membranes, Artificial ; Middle Aged ; Mucosa ; Peri-Implantitis - diagnostic imaging ; Peri-Implantitis - surgery ; Periodontal Attachment Loss ; Periodontal Index ; peri‐implant defect ; peri‐implantitis ; Recession ; Regeneration ; Statistical analysis ; Statistical significance ; Substitute bone ; Surgery ; Surgical implants ; Transplants & implants ; Treatment Outcome</subject><ispartof>Clinical implant dentistry and related research, 2018-10, Vol.20 (5), p.703-712</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-c43e17f518e8afa895425759746b0a5972edb130113b0ea2b038ea5b018fdd433</citedby><cites>FETCH-LOGICAL-c3531-c43e17f518e8afa895425759746b0a5972edb130113b0ea2b038ea5b018fdd433</cites><orcidid>0000-0001-5419-9658</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcid.12661$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcid.12661$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30118569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isler, Sila Cagri</creatorcontrib><creatorcontrib>Soysal, Fatma</creatorcontrib><creatorcontrib>Ceyhanlı, Tugce</creatorcontrib><creatorcontrib>Bakırarar, Batuhan</creatorcontrib><creatorcontrib>Unsal, Berrin</creatorcontrib><title>Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial</title><title>Clinical implant dentistry and related research</title><addtitle>Clin Implant Dent Relat Res</addtitle><description>Background
Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD).
Purpose
The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri‐implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12‐month follow‐up.
Materials and Methods
Fifty two patients, who had at least one peri‐implantitis lesion was treated by using a bone substitute in combination with CGF or CM. After surgical procedures, implants were allowed for submerged healing. Clinical assessments were conducted at baseline, 6 and 12 months postoperatively, while radiographic evaluation was performed at baseline and 12 months.
Results
Significant reductions were obtained in the mean gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession (MR) values at both 6 and 12 months postoperatively compared to baseline for both treatment procedures (P < 0.05). At 6 months, no statistically significant difference was observed for all clinical parameters between the groups, whereas the mean PD, CAL and vertical defect depth (VDD) values were statistically significant in favor of the CM group at 12 months (P < 0.05). The mean defect fill (DF) in the CM group (1.99 ±0.76) was not statistically significantly different from that observed in the CCF group (1.63 ±1.00) (P = 0.154).
Conclusions
The outcomes of the present study suggest that both regenerative approaches yielded significant improvements in both clinical and radiographic assessments. The procedure using a collagen membrane in combination with a bone substitute showed better results at 12 months in RST of peri‐implantitis.</description><subject>Assessments</subject><subject>barrier membranes</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bleeding</subject><subject>Bone biomaterials</subject><subject>Bone growth</subject><subject>Bone implants</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Clinical trials</subject><subject>Collagen</subject><subject>Collagen - therapeutic use</subject><subject>concentrated growth factor</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gingival index</subject><subject>Growth factors</subject><subject>guided bone regeneration</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - therapeutic use</subject><subject>Male</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Peri-Implantitis - diagnostic imaging</subject><subject>Peri-Implantitis - surgery</subject><subject>Periodontal Attachment Loss</subject><subject>Periodontal Index</subject><subject>peri‐implant defect</subject><subject>peri‐implantitis</subject><subject>Recession</subject><subject>Regeneration</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Substitute bone</subject><subject>Surgery</subject><subject>Surgical implants</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><issn>1523-0899</issn><issn>1708-8208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtuFDEQhi0EIg9YcAFkiQ1ZdOLHuNvNLhpekSIhIVhbbnf1xFHbHmx3orDiCByA03ESKszAAglvbJU-f6qqn5BnnJ1yPGfOj6dctC1_QA55x3SjBdMP8a2EbJju-wNyVMo1Y4Lzlj8mB5JxrlXbH5IfH2EDEbKt_gZoWfLGOzvTmsHWALHSNNEtZP_z23cftrON1Vdf6FJ83FDw9QoytdSlebbooQHCkG0EmjIWo0MDqmGkm5xu6xWdrKspv6LnlAtUhhSxiB_GFPxXxNzs474Bb-cn5NFk5wJP9_cx-fz2zaf1--byw7uL9fll46SSvHErCbybFNeg7WR1r1ZCdarvVu3ALN4CxoHfzywHBlYMTGqwamBcT-O4kvKYvNx5tzl9WaBUE3xxgDNFSEsxuM1eK6V4h-iLf9DrtOSI3Rlcbte1TGiN1MmOcjmVkmEy2-yDzXeGM3MfmcHIzO_IkH2-Ny5DgPEv-ScjBM52wK2f4e7_JrO-eL1T_gJQdqOo</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Isler, Sila Cagri</creator><creator>Soysal, Fatma</creator><creator>Ceyhanlı, Tugce</creator><creator>Bakırarar, Batuhan</creator><creator>Unsal, Berrin</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5419-9658</orcidid></search><sort><creationdate>201810</creationdate><title>Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial</title><author>Isler, Sila Cagri ; Soysal, Fatma ; Ceyhanlı, Tugce ; Bakırarar, Batuhan ; Unsal, Berrin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-c43e17f518e8afa895425759746b0a5972edb130113b0ea2b038ea5b018fdd433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Assessments</topic><topic>barrier membranes</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bleeding</topic><topic>Bone biomaterials</topic><topic>Bone growth</topic><topic>Bone implants</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Clinical trials</topic><topic>Collagen</topic><topic>Collagen - therapeutic use</topic><topic>concentrated growth factor</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gingival index</topic><topic>Growth factors</topic><topic>guided bone regeneration</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - therapeutic use</topic><topic>Male</topic><topic>Membranes</topic><topic>Membranes, Artificial</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Peri-Implantitis - diagnostic imaging</topic><topic>Peri-Implantitis - surgery</topic><topic>Periodontal Attachment Loss</topic><topic>Periodontal Index</topic><topic>peri‐implant defect</topic><topic>peri‐implantitis</topic><topic>Recession</topic><topic>Regeneration</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Substitute bone</topic><topic>Surgery</topic><topic>Surgical implants</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isler, Sila Cagri</creatorcontrib><creatorcontrib>Soysal, Fatma</creatorcontrib><creatorcontrib>Ceyhanlı, Tugce</creatorcontrib><creatorcontrib>Bakırarar, Batuhan</creatorcontrib><creatorcontrib>Unsal, Berrin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical implant dentistry and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isler, Sila Cagri</au><au>Soysal, Fatma</au><au>Ceyhanlı, Tugce</au><au>Bakırarar, Batuhan</au><au>Unsal, Berrin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial</atitle><jtitle>Clinical implant dentistry and related research</jtitle><addtitle>Clin Implant Dent Relat Res</addtitle><date>2018-10</date><risdate>2018</risdate><volume>20</volume><issue>5</issue><spage>703</spage><epage>712</epage><pages>703-712</pages><issn>1523-0899</issn><eissn>1708-8208</eissn><abstract>Background
Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD).
Purpose
The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri‐implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12‐month follow‐up.
Materials and Methods
Fifty two patients, who had at least one peri‐implantitis lesion was treated by using a bone substitute in combination with CGF or CM. After surgical procedures, implants were allowed for submerged healing. Clinical assessments were conducted at baseline, 6 and 12 months postoperatively, while radiographic evaluation was performed at baseline and 12 months.
Results
Significant reductions were obtained in the mean gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession (MR) values at both 6 and 12 months postoperatively compared to baseline for both treatment procedures (P < 0.05). At 6 months, no statistically significant difference was observed for all clinical parameters between the groups, whereas the mean PD, CAL and vertical defect depth (VDD) values were statistically significant in favor of the CM group at 12 months (P < 0.05). The mean defect fill (DF) in the CM group (1.99 ±0.76) was not statistically significantly different from that observed in the CCF group (1.63 ±1.00) (P = 0.154).
Conclusions
The outcomes of the present study suggest that both regenerative approaches yielded significant improvements in both clinical and radiographic assessments. The procedure using a collagen membrane in combination with a bone substitute showed better results at 12 months in RST of peri‐implantitis.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30118569</pmid><doi>10.1111/cid.12661</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5419-9658</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Assessments barrier membranes Biocompatibility Biomedical materials Bleeding Bone biomaterials Bone growth Bone implants Bone Substitutes - therapeutic use Clinical trials Collagen Collagen - therapeutic use concentrated growth factor Dentistry Female Gingival index Growth factors guided bone regeneration Humans Intercellular Signaling Peptides and Proteins - therapeutic use Male Membranes Membranes, Artificial Middle Aged Mucosa Peri-Implantitis - diagnostic imaging Peri-Implantitis - surgery Periodontal Attachment Loss Periodontal Index peri‐implant defect peri‐implantitis Recession Regeneration Statistical analysis Statistical significance Substitute bone Surgery Surgical implants Transplants & implants Treatment Outcome |
| title | Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial |
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