Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial

Background Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri‐implant bone defects (PBD). Purpose The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri‐implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12‐month follow‐up. Materials and Methods Fifty two patients, who had at least one peri‐implantitis lesion was treated by using a bone substitute in combination with CGF or CM. After surgical procedures, implants were allowed for submerged healing. Clinical assessments were conducted at baseline, 6 and 12 months postoperatively, while radiographic evaluation was performed at baseline and 12 months. Results Significant reductions were obtained in the mean gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession (MR) values at both 6 and 12 months postoperatively compared to baseline for both treatment procedures (P