Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma
Objectives To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy. Methods We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radica...
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| Veröffentlicht in: | International journal of urology 2018-10, Vol.25 (10), p.871-878 |
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| container_title | International journal of urology |
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| creator | Otsuka, Masafumi Kamasako, Tomohiko Uemura, Toshihiro Takeshita, Nobushige Shinozaki, Tetsuo Kobayashi, Masayuki Komaru, Atsushi Fukasawa, Satoshi |
| description | Objectives
To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy.
Methods
We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein − albumin). Associations between preoperative clinicopathological factors, including the albumin : globulin ratio, and recurrence‐free survival, cancer‐specific survival and overall survival were assessed. The log–rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin : globulin ratio cut‐off value determined using receiver operating characteristic curve analysis.
Results
The median survival time was 55 months (interquartile range 28–76 months), and 31 patients died during follow up. A low preoperative albumin : globulin ratio |
| doi_str_mv | 10.1111/iju.13767 |
| format | Article |
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To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy.
Methods
We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein − albumin). Associations between preoperative clinicopathological factors, including the albumin : globulin ratio, and recurrence‐free survival, cancer‐specific survival and overall survival were assessed. The log–rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin : globulin ratio cut‐off value determined using receiver operating characteristic curve analysis.
Results
The median survival time was 55 months (interquartile range 28–76 months), and 31 patients died during follow up. A low preoperative albumin : globulin ratio <1.40 was associated with tumor grade and surgical margin status. Kaplan–Meier analyses showed that a low albumin : globulin ratio was more significantly correlated with worse recurrence‐free survival, cancer‐specific survival and overall survival. Multivariate analyses showed that a low albumin : globulin ratio was an independent predictive factor associated with poor recurrence‐free survival (hazard ratio 3.758; P = 0.0028), cancer‐specific survival (hazard ratio 5.687; P = 0.0044) and overall survival (hazard ratio 3.124; P = 0.0030).
Conclusions
A low albumin : globulin ratio is an independent predictive factor associated with poor prognosis in upper tract urothelial carcinoma patients treated with radical nephroureterectomy.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.13767</identifier><identifier>PMID: 30103271</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Aged ; Albumin ; albumin : globulin ratio ; Cancer ; cancer‐specific survival ; Carcinoma, Transitional Cell - blood ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Globulins ; Humans ; Kaplan-Meier Estimate ; Kidney Neoplasms - blood ; Kidney Neoplasms - mortality ; Kidney Neoplasms - surgery ; Male ; Medical prognosis ; Nephroureterectomy ; overall survival ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Retrospective Studies ; Serum Albumin, Human - analysis ; Serum Globulins - analysis ; Survival ; upper tract urothelial carcinoma ; Ureteral Neoplasms - blood ; Ureteral Neoplasms - mortality ; Ureteral Neoplasms - surgery ; Urothelial carcinoma</subject><ispartof>International journal of urology, 2018-10, Vol.25 (10), p.871-878</ispartof><rights>2018 The Japanese Urological Association</rights><rights>2018 The Japanese Urological Association.</rights><rights>Copyright © 2018 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4787-386661f7b9f19a6f797d94e6768d523697bc2355d6a0b1807b7cae890a02721b3</citedby><cites>FETCH-LOGICAL-c4787-386661f7b9f19a6f797d94e6768d523697bc2355d6a0b1807b7cae890a02721b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.13767$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.13767$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30103271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otsuka, Masafumi</creatorcontrib><creatorcontrib>Kamasako, Tomohiko</creatorcontrib><creatorcontrib>Uemura, Toshihiro</creatorcontrib><creatorcontrib>Takeshita, Nobushige</creatorcontrib><creatorcontrib>Shinozaki, Tetsuo</creatorcontrib><creatorcontrib>Kobayashi, Masayuki</creatorcontrib><creatorcontrib>Komaru, Atsushi</creatorcontrib><creatorcontrib>Fukasawa, Satoshi</creatorcontrib><title>Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy.
Methods
We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein − albumin). Associations between preoperative clinicopathological factors, including the albumin : globulin ratio, and recurrence‐free survival, cancer‐specific survival and overall survival were assessed. The log–rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin : globulin ratio cut‐off value determined using receiver operating characteristic curve analysis.
Results
The median survival time was 55 months (interquartile range 28–76 months), and 31 patients died during follow up. A low preoperative albumin : globulin ratio <1.40 was associated with tumor grade and surgical margin status. Kaplan–Meier analyses showed that a low albumin : globulin ratio was more significantly correlated with worse recurrence‐free survival, cancer‐specific survival and overall survival. Multivariate analyses showed that a low albumin : globulin ratio was an independent predictive factor associated with poor recurrence‐free survival (hazard ratio 3.758; P = 0.0028), cancer‐specific survival (hazard ratio 5.687; P = 0.0044) and overall survival (hazard ratio 3.124; P = 0.0030).
Conclusions
A low albumin : globulin ratio is an independent predictive factor associated with poor prognosis in upper tract urothelial carcinoma patients treated with radical nephroureterectomy.</description><subject>Aged</subject><subject>Albumin</subject><subject>albumin : globulin ratio</subject><subject>Cancer</subject><subject>cancer‐specific survival</subject><subject>Carcinoma, Transitional Cell - blood</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Globulins</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Neoplasms - blood</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Nephroureterectomy</subject><subject>overall survival</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Serum Albumin, Human - analysis</subject><subject>Serum Globulins - analysis</subject><subject>Survival</subject><subject>upper tract urothelial carcinoma</subject><subject>Ureteral Neoplasms - blood</subject><subject>Ureteral Neoplasms - mortality</subject><subject>Ureteral Neoplasms - surgery</subject><subject>Urothelial carcinoma</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFuFSEUBmBibOy1uvAFDIkbXUzLgRkY3JlGbU0TXdj1hGHOtNwwwwiD5r6CT9Fn6ZNJva0Lk7KBkC8_h_yEvAJ2DGWduG0-BqGkekI2UNe84qzmT8mGadBVC4ofkucpbRkDwaF9Rg4FAya4gg35_S2Gqzmk1Vkag0caRrpeI10ihgWjWd1PpAljnqjxfZ7cfHvz_vbmyoc-ezfTOxGoGVeM5Tw4azydcbmOIUcsl2jXMO3oGCLNSwmkazR2pTmG8op3RVsTrZvDZF6Qg9H4hC_v9yNy-enj99Oz6uLr5_PTDxeVrVWrKtFKKWFUvR5BGzkqrQZdo1SyHRoupFa95aJpBmlYDy1TvbIGW80M44pDL47I233uEsOPjGntJpcsem9mDDl1nLUt1yBBF_rmP7ot_5rLdB0HaDjoRkBR7_bKxpBSxLFboptM3HXAuruCulJQ97egYl_fJ-Z-wuGffGikgJM9-OU87h5P6s6_XO4j_wDYiZ2J</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Otsuka, Masafumi</creator><creator>Kamasako, Tomohiko</creator><creator>Uemura, Toshihiro</creator><creator>Takeshita, Nobushige</creator><creator>Shinozaki, Tetsuo</creator><creator>Kobayashi, Masayuki</creator><creator>Komaru, Atsushi</creator><creator>Fukasawa, Satoshi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma</title><author>Otsuka, Masafumi ; Kamasako, Tomohiko ; Uemura, Toshihiro ; Takeshita, Nobushige ; Shinozaki, Tetsuo ; Kobayashi, Masayuki ; Komaru, Atsushi ; Fukasawa, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4787-386661f7b9f19a6f797d94e6768d523697bc2355d6a0b1807b7cae890a02721b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Albumin</topic><topic>albumin : globulin ratio</topic><topic>Cancer</topic><topic>cancer‐specific survival</topic><topic>Carcinoma, Transitional Cell - blood</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Globulins</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Neoplasms - blood</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Nephroureterectomy</topic><topic>overall survival</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Serum Albumin, Human - analysis</topic><topic>Serum Globulins - analysis</topic><topic>Survival</topic><topic>upper tract urothelial carcinoma</topic><topic>Ureteral Neoplasms - blood</topic><topic>Ureteral Neoplasms - mortality</topic><topic>Ureteral Neoplasms - surgery</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otsuka, Masafumi</creatorcontrib><creatorcontrib>Kamasako, Tomohiko</creatorcontrib><creatorcontrib>Uemura, Toshihiro</creatorcontrib><creatorcontrib>Takeshita, Nobushige</creatorcontrib><creatorcontrib>Shinozaki, Tetsuo</creatorcontrib><creatorcontrib>Kobayashi, Masayuki</creatorcontrib><creatorcontrib>Komaru, Atsushi</creatorcontrib><creatorcontrib>Fukasawa, Satoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otsuka, Masafumi</au><au>Kamasako, Tomohiko</au><au>Uemura, Toshihiro</au><au>Takeshita, Nobushige</au><au>Shinozaki, Tetsuo</au><au>Kobayashi, Masayuki</au><au>Komaru, Atsushi</au><au>Fukasawa, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>25</volume><issue>10</issue><spage>871</spage><epage>878</epage><pages>871-878</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy.
Methods
We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein − albumin). Associations between preoperative clinicopathological factors, including the albumin : globulin ratio, and recurrence‐free survival, cancer‐specific survival and overall survival were assessed. The log–rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin : globulin ratio cut‐off value determined using receiver operating characteristic curve analysis.
Results
The median survival time was 55 months (interquartile range 28–76 months), and 31 patients died during follow up. A low preoperative albumin : globulin ratio <1.40 was associated with tumor grade and surgical margin status. Kaplan–Meier analyses showed that a low albumin : globulin ratio was more significantly correlated with worse recurrence‐free survival, cancer‐specific survival and overall survival. Multivariate analyses showed that a low albumin : globulin ratio was an independent predictive factor associated with poor recurrence‐free survival (hazard ratio 3.758; P = 0.0028), cancer‐specific survival (hazard ratio 5.687; P = 0.0044) and overall survival (hazard ratio 3.124; P = 0.0030).
Conclusions
A low albumin : globulin ratio is an independent predictive factor associated with poor prognosis in upper tract urothelial carcinoma patients treated with radical nephroureterectomy.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30103271</pmid><doi>10.1111/iju.13767</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Albumin albumin : globulin ratio Cancer cancer‐specific survival Carcinoma, Transitional Cell - blood Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - surgery Disease-Free Survival Female Follow-Up Studies Globulins Humans Kaplan-Meier Estimate Kidney Neoplasms - blood Kidney Neoplasms - mortality Kidney Neoplasms - surgery Male Medical prognosis Nephroureterectomy overall survival Predictive Value of Tests Preoperative Period Prognosis Retrospective Studies Serum Albumin, Human - analysis Serum Globulins - analysis Survival upper tract urothelial carcinoma Ureteral Neoplasms - blood Ureteral Neoplasms - mortality Ureteral Neoplasms - surgery Urothelial carcinoma |
| title | Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma |
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