Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

Objectives To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy. Methods We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein − albumin). Associations between preoperative clinicopathological factors, including the albumin : globulin ratio, and recurrence‐free survival, cancer‐specific survival and overall survival were assessed. The log–rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin : globulin ratio cut‐off value determined using receiver operating characteristic curve analysis. Results The median survival time was 55 months (interquartile range 28–76 months), and 31 patients died during follow up. A low preoperative albumin : globulin ratio