Modifying the physicochemical properties of NSAIDs for nasal and pulmonary administration

[Display omitted] This review focuses on nasal and pulmonary delivery of NSAIDs (non-steroidal anti-inflammatory drugs) for fast-onset analgesia, for the potential prevention of Alzheimer’s disease (AD), as well as for an add-on treatment in cystic fibrosis (CF) and non-small cell lung cancer (NSCLC...

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Veröffentlicht in:	Drug discovery today. Technologies 2018-07, Vol.27, p.87-93
1. Verfasser:	Szabó-Révész, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Intranasal Alzheimer Disease - prevention & control Analgesia Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Cystic Fibrosis - drug therapy Dosage Forms Humans Lung - metabolism Lung Neoplasms - drug therapy
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Zusammenfassung:	[Display omitted] This review focuses on nasal and pulmonary delivery of NSAIDs (non-steroidal anti-inflammatory drugs) for fast-onset analgesia, for the potential prevention of Alzheimer’s disease (AD), as well as for an add-on treatment in cystic fibrosis (CF) and non-small cell lung cancer (NSCLC). I discuss how the physicochemical properties of NSAIDs can be modified with respect to the biological characteristics of the target site. Innovative technology and/or dosage forms can promote an effective therapy.
ISSN:	1740-6749 1740-6749
DOI:	10.1016/j.ddtec.2018.03.002