Regioselective Access to 3‑Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C–C and C–N Cascade Coupling Reactions from the Substituted 2‑(Cyanomethyl)benzonitriles
A novel and regioselective Ni(I) catalyzed C–C and C–N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines. The regioselectivity of C(sp3)-cyano group over C(sp2)-cyano group was revealed and supported by mechanism studies as...
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| Veröffentlicht in: | Journal of organic chemistry 2018-09, Vol.83 (17), p.9682-9695 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A novel and regioselective Ni(I) catalyzed C–C and C–N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines. The regioselectivity of C(sp3)-cyano group over C(sp2)-cyano group was revealed and supported by mechanism studies as well as the preliminary density functional theory (DFT) calculations. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.8b01159 |