Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE−/−mice

Abstract Aims The immune system is considered a key driver of atherosclerosis, and beyond proteins and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in immune control. We previously described that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cardiovascular research 2019-02, Vol.115 (2), p.302-314
Hauptverfasser:	Gast, Martina, Rauch, Bernhard H, Nakagawa, Shinichi, Haghikia, Arash, Jasina, Andrzej, Haas, Jan, Nath, Neetika, Jensen, Lars, Stroux, Andrea, Böhm, Andreas, Friebel, Julian, Rauch, Ursula, Skurk, Carsten, Blankenberg, Stefan, Zeller, Tanja, Prasanth, Kannanganattu V, Meder, Benjamin, Kuss, Andreas, Landmesser, Ulf, Poller, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - immunology Aorta - metabolism Aorta - pathology Aortic Diseases - genetics Aortic Diseases - immunology Aortic Diseases - metabolism Aortic Diseases - pathology Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Cells, Cultured Cytokines - blood Cytokines - immunology Disease Models, Animal Disease Progression Inflammation Mediators - blood Inflammation Mediators - immunology Macrophages - immunology Macrophages - metabolism Mice, Inbred C57BL Mice, Knockout, ApoE Plaque, Atherosclerotic RNA, Long Noncoding - genetics RNA, Long Noncoding - immunology RNA, Long Noncoding - metabolism Spleen - immunology Spleen - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Aims The immune system is considered a key driver of atherosclerosis, and beyond proteins and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in immune control. We previously described that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in cardiac innate immunity in a myocarditis model. Here, we investigated the impact of MALAT1 deficiency upon atherosclerosis development. Methods and results Heterozygous MALAT1-deficient ApoE−/− mice displayed massive immune system dysregulation and atherosclerosis within 2 months even when kept on normal diet. Aortic plaque area (P
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/cvy202