Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain

Despite high sequence homology among the p53 family members, the regulation of their transactivation potential is based on strikingly different mechanisms. Previous studies revealed that the activity of TAp63α is regulated via an autoinhibitory mechanism that keeps inactive TAp63α in a dimeric confo...

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Veröffentlicht in:	Structure (London) 2018-08, Vol.26 (8), p.1091-1100.e4
Hauptverfasser:	Krauskopf, Katharina, Gebel, Jakob, Kazemi, Sina, Tuppi, Marcel, Löhr, Frank, Schäfer, Birgit, Koch, Joachim, Güntert, Peter, Dötsch, Volker, Kehrloesser, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	autoinhibition CBP oligomerization p300 p53 family p63 p73
Online-Zugang:	Volltext
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