Impact of obesity on outcomes for patients with head and neck cancer

•The effect of obesity on outcomes in head and neck cancer (HNC) is unclear.•High BMI at diagnosis is associated with improved overall survival.•Obesity is associated with improved distant control, not locoregional control.•BMI is prognostic in HNC, independent of clinical, treatment and pathologic...

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Veröffentlicht in:Oral oncology 2018-08, Vol.83, p.11-17
Hauptverfasser: Hicks, Daniel F., Bakst, Richard, Doucette, John, Kann, Benjamin H., Miles, Brett, Genden, Eric, Misiukiewicz, Krzysztof, Posner, Marshall, Gupta, Vishal
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Sprache:eng
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Zusammenfassung:•The effect of obesity on outcomes in head and neck cancer (HNC) is unclear.•High BMI at diagnosis is associated with improved overall survival.•Obesity is associated with improved distant control, not locoregional control.•BMI is prognostic in HNC, independent of clinical, treatment and pathologic factors. The prognostic role of obesity in head and neck squamous cell carcinoma (HNSCC) is not well defined. This study aims to determine its effect on disease-specific outcomes such as recurrence-free survival (RFS), locoregional recurrence-free survival (LRRFS), and distant metastasis-free survival (DMFS) in addition to overall survival (OS). For patients with newly diagnosed HNSCC undergoing radiation therapy (RT) at a single institution, body mass index (BMI) at diagnosis was categorized as normal (18.5 to 24.9 kg/m2), overweight (25 to 29.9 kg/m2) and obese (≥30 kg/m2). Outcomes were compared by BMI group using Cox regression. 341 patients of median age 59 (range, 20–93) who underwent curative RT from 2010 to 2017 were included. 58% had oropharynx cancer, 17% larynx and 15% oral cavity. 72% had stage IVA/B disease and 28% stage I-III. At diagnosis, 33% had normal BMI, 40% overweight, and 28% obese. 59% had definitive RT and 41% had postoperative RT. Alcoholic/smoking status, advanced tumor stage, hypopharynx/larynx tumors, and feeding tube placement were more common in patients with lower BMI (P 
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2018.05.027