Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression

Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomy...

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Veröffentlicht in:	Journal of investigative medicine 2019-01, Vol.67 (1), p.11-19
Hauptverfasser:	Pawlak, Agnieszka, Rejmak-Kozicka, Emilia, Gil, Katarzyna Elżbieta, Ziemba, Andrzej, Kaczmarek, Leszek, Gil, Robert Julian
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiomyocytes Cardiomyopathy Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Desmin - genetics Desmin - metabolism Disease Ejection fraction Female Fibrosis Gene expression Gene Expression Regulation Heart failure Humans Kinases Male Middle Aged Mutation Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Natriuretic Peptide, Brain - metabolism Peptide Fragments - metabolism Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Ubiquitin - genetics Ubiquitin - metabolism
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Zusammenfassung:	Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomyocytes. Endomyocardial biopsy was performed in 60 patients (85% men, mean age 46±14 years) with heart failure (HF; left ventricular ejection fraction
ISSN:	1081-5589 1708-8267
DOI:	10.1136/jim-2017-000707