A light-triggered transmembrane porin

A light-triggered transmembrane porin

Porins are ideal model systems for channel engineering. OmpG is a robust, monomeric, transmembrane β-barrel without ion selectivity. Here, we present a photocaged diethylaminocoumarin (DEACM) hybrid of OmpG. Blockage of the pore by DEACM is confirmed by reduced conductivity. An optimal effect was ob...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (69), p.9623-9626
Hauptverfasser: Kahlstatt, J, Reiß, P, Halbritter, T, Essen, L-O, Koert, U, Heckel, A
Format: Artikel
Sprache:eng
Schlagworte:
Cages
Coumarin
Restoration
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Beschreibung
Zusammenfassung:Porins are ideal model systems for channel engineering. OmpG is a robust, monomeric, transmembrane β-barrel without ion selectivity. Here, we present a photocaged diethylaminocoumarin (DEACM) hybrid of OmpG. Blockage of the pore by DEACM is confirmed by reduced conductivity. An optimal effect was obtained when two bulky butyl-substituted coumarin cages were attached on the inside of the pore. Irradiation at 385 nm removed the photocages, leading to a restoration of channel conductivity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05221b