Preparation of α-Cyclodextrin-Terminated Polyrotaxane Consisting of β-Cyclodextrins and Pluronic as a Building Block of a Biodegradable Network

A β‐CD‐based biodegradable polyrotaxane was prepared by capping both terminals of polypseudorotaxane consisting of hydrazide‐terminated PEG‐block‐PPG‐block‐PEG (Pluronic P‐105®) and β‐CD‐succinates with mono‐aldehyde α‐CDs. By decreasing pH, the fluorescent intensity of TNS was increased with time, indicating cleavage of the terminal hydrazone bonds followed by β‐CD‐succinate release. The terminal α‐CD moieties of the polyrotaxane are useful for self‐assembled formation with some guest molecules.