Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier
In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-amm...
Gespeichert in:
| Veröffentlicht in: | Langmuir 2019-02, Vol.35 (5), p.1495-1502 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1502 |
|---|---|
| container_issue | 5 |
| container_start_page | 1495 |
| container_title | Langmuir |
| container_volume | 35 |
| creator | Zhang, Jing Chen, Liqun Chen, Jiada Zhang, Quan Feng, Jie |
| description | In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days. |
| doi_str_mv | 10.1021/acs.langmuir.8b01995 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2086258288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2086258288</sourcerecordid><originalsourceid>FETCH-LOGICAL-a348t-65fec8ba80bf2b4c8e5911e17265c629b93250df694c930c0812ef05289eb33e3</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EoqXwDxDyyEDKtR2n9ojKUwIx8BhYIse5ad2mSbEToP-eVG0Zme7ynXN1PkJOGQwZcHZpbBiWpposWueHKgOmtdwjfSY5RFLx0T7pwygW0ShORI8chTADAC1ifUh6AkBpIXWfTF8ak7nSNasLOsaybEvj6duyMXO8oKbKqavou_uq6as3du6qCa0L-vHtmga9qyv6VOeucJjTO2-WU6yQPv-4HKkJ1NBr307o2Hjv0B-Tg8KUAU-2d0Debm9ex_fR4_Pdw_jqMTIiVk2UyAKtyoyCrOBZbBVKzRiyEU-kTbjOtOAS8iLRsdUCLCjGsQDJlcZMCBQDcr7pXfr6s8XQpAsXbLfMVFi3IeWgEt75UapD4w1qfR2CxyJdercwfpUySNeO085xunOcbh13sbPthzZbYP4X2kntANgA6_isbn3VDf6_8xfCa4to</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2086258288</pqid></control><display><type>article</type><title>Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Zhang, Jing ; Chen, Liqun ; Chen, Jiada ; Zhang, Quan ; Feng, Jie</creator><creatorcontrib>Zhang, Jing ; Chen, Liqun ; Chen, Jiada ; Zhang, Quan ; Feng, Jie</creatorcontrib><description>In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/acs.langmuir.8b01995</identifier><identifier>PMID: 30089359</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Doxorubicin - pharmacology ; Drug Carriers - chemistry ; Drug Carriers - toxicity ; Drug Liberation ; Graphite - chemistry ; Graphite - toxicity ; Hep G2 Cells ; Humans ; Silanes - chemistry ; Silanes - toxicity ; Zebrafish</subject><ispartof>Langmuir, 2019-02, Vol.35 (5), p.1495-1502</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-65fec8ba80bf2b4c8e5911e17265c629b93250df694c930c0812ef05289eb33e3</citedby><cites>FETCH-LOGICAL-a348t-65fec8ba80bf2b4c8e5911e17265c629b93250df694c930c0812ef05289eb33e3</cites><orcidid>0000-0001-9112-0662 ; 0000-0002-0245-7149 ; 0000-0001-7228-117X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.8b01995$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.langmuir.8b01995$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30089359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chen, Liqun</creatorcontrib><creatorcontrib>Chen, Jiada</creatorcontrib><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Feng, Jie</creatorcontrib><title>Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - toxicity</subject><subject>Drug Liberation</subject><subject>Graphite - chemistry</subject><subject>Graphite - toxicity</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Silanes - chemistry</subject><subject>Silanes - toxicity</subject><subject>Zebrafish</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwDxDyyEDKtR2n9ojKUwIx8BhYIse5ad2mSbEToP-eVG0Zme7ynXN1PkJOGQwZcHZpbBiWpposWueHKgOmtdwjfSY5RFLx0T7pwygW0ShORI8chTADAC1ifUh6AkBpIXWfTF8ak7nSNasLOsaybEvj6duyMXO8oKbKqavou_uq6as3du6qCa0L-vHtmga9qyv6VOeucJjTO2-WU6yQPv-4HKkJ1NBr307o2Hjv0B-Tg8KUAU-2d0Debm9ex_fR4_Pdw_jqMTIiVk2UyAKtyoyCrOBZbBVKzRiyEU-kTbjOtOAS8iLRsdUCLCjGsQDJlcZMCBQDcr7pXfr6s8XQpAsXbLfMVFi3IeWgEt75UapD4w1qfR2CxyJdercwfpUySNeO085xunOcbh13sbPthzZbYP4X2kntANgA6_isbn3VDf6_8xfCa4to</recordid><startdate>20190205</startdate><enddate>20190205</enddate><creator>Zhang, Jing</creator><creator>Chen, Liqun</creator><creator>Chen, Jiada</creator><creator>Zhang, Quan</creator><creator>Feng, Jie</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9112-0662</orcidid><orcidid>https://orcid.org/0000-0002-0245-7149</orcidid><orcidid>https://orcid.org/0000-0001-7228-117X</orcidid></search><sort><creationdate>20190205</creationdate><title>Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier</title><author>Zhang, Jing ; Chen, Liqun ; Chen, Jiada ; Zhang, Quan ; Feng, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-65fec8ba80bf2b4c8e5911e17265c629b93250df694c930c0812ef05289eb33e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - toxicity</topic><topic>Drug Liberation</topic><topic>Graphite - chemistry</topic><topic>Graphite - toxicity</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Silanes - chemistry</topic><topic>Silanes - toxicity</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chen, Liqun</creatorcontrib><creatorcontrib>Chen, Jiada</creatorcontrib><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Feng, Jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jing</au><au>Chen, Liqun</au><au>Chen, Jiada</au><au>Zhang, Quan</au><au>Feng, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2019-02-05</date><risdate>2019</risdate><volume>35</volume><issue>5</issue><spage>1495</spage><epage>1502</epage><pages>1495-1502</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><abstract>In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>30089359</pmid><doi>10.1021/acs.langmuir.8b01995</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9112-0662</orcidid><orcidid>https://orcid.org/0000-0002-0245-7149</orcidid><orcidid>https://orcid.org/0000-0001-7228-117X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-7463 |
| ispartof | Langmuir, 2019-02, Vol.35 (5), p.1495-1502 |
| issn | 0743-7463 1520-5827 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2086258288 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic Agents - pharmacology Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - toxicity Drug Liberation Graphite - chemistry Graphite - toxicity Hep G2 Cells Humans Silanes - chemistry Silanes - toxicity Zebrafish |
| title | Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T15%3A36%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stability,%20Cellular%20Uptake,%20and%20in%20Vivo%20Tracking%20of%20Zwitterion%20Modified%20Graphene%20Oxide%20as%20a%20Drug%20Carrier&rft.jtitle=Langmuir&rft.au=Zhang,%20Jing&rft.date=2019-02-05&rft.volume=35&rft.issue=5&rft.spage=1495&rft.epage=1502&rft.pages=1495-1502&rft.issn=0743-7463&rft.eissn=1520-5827&rft_id=info:doi/10.1021/acs.langmuir.8b01995&rft_dat=%3Cproquest_cross%3E2086258288%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2086258288&rft_id=info:pmid/30089359&rfr_iscdi=true |