The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro

The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro

To identify purine analogs that could be effective in treating neuroblastomas, we tested the anticancer properties of sulfinosine, 8-Cl-cAMP and 8-Cl-adenosine in the SK-N-SH cell line. First we examined the effects of these three agents on cell growth inhibition and cell viability by the BrdU and S...

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Veröffentlicht in:Investigational new drugs 2006-01, Vol.24 (1), p.15-25
Hauptverfasser: Janković, Dragana, Pesić, Milica, Marković, Jasna, Kanazir, Selma, Marković, Ivanka, Rakić, Ljubisav, Ruzdijić, Sabera
Format: Artikel
Sprache:eng
Schlagworte:
2-Chloroadenosine - analogs & derivatives
2-Chloroadenosine - pharmacology
8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives
8-Bromo Cyclic Adenosine Monophosphate - pharmacology
Adenosine
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Cancer therapies
Cell culture
Cell cycle
Cell death
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Drug dosages
Drug Synergism
Ewings sarcoma
Humans
Investigations
Kinases
Leukemia
Neuroblastoma
Neurosciences
Purine Nucleosides - pharmacology
Time Factors
Tumors
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Zusammenfassung:To identify purine analogs that could be effective in treating neuroblastomas, we tested the anticancer properties of sulfinosine, 8-Cl-cAMP and 8-Cl-adenosine in the SK-N-SH cell line. First we examined the effects of these three agents on cell growth inhibition and cell viability by the BrdU and Sulforhodamine B assay. Treatment of SK-N-SH cells with increasing concentrations of these compounds led to a significant inhibition of cell proliferation and decrease of cell viability in a time- and dose-dependent manner at micromolar concentration (
ISSN:0167-6997
1573-0646
DOI:10.1007/s10637-005-4539-8