The role of OPRM1 polymorphism in the etiology of alcoholism

Numerous studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results have been inconsistent. The endogenous opioid system has been implicated in the development of alcohol dependence for its prominent role in the central rewardin...

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Veröffentlicht in:	Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2019-02, Vol.28 (2), p.199-202
Hauptverfasser:	Samochowiec, Agnieszka, Samochowiec, Jerzy, Pełka-Wysiecka, Justyna, Kucharska-Mazur, Jolanta, Grochans, Elżbieta, Jabłoński, Marcin, Bieńkowski, Przemysław, Murawiec, Sławomir, Małecka, Iwona, Mak, Monika, Kołodziej, Łukasz, Heitzman, Janusz, Grzywacz, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcoholism - etiology Alcoholism - genetics Alleles Case-Control Studies Genotype Humans Middle Aged Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Receptors, Opioid, mu - genetics
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Zusammenfassung:	Numerous studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results have been inconsistent. The endogenous opioid system has been implicated in the development of alcohol dependence for its prominent role in the central rewarding mechanism. The aim of this study was to evaluate the role of the A118G polymorphism of the OPRM1 gene in the pathogenesis of alcohol dependence syndrome (ADS). The OPRM1 (rs1799971) polymorphism was investigated in an association study of a group of ADS patients (n = 177) and in subgroups (delirium tremens and/or seizures, age at onset
ISSN:	1899-5276
DOI:	10.17219/acem/78592