An evaluation of the cognitive and mood effects of administration with a multivitamin and mineral supplement for 12 weeks in schoolchildren

Adequate consumption of vitamins and minerals is essential for the optimal performance of a host of physiological processes that have both direct and indirect effects on brain function, yet modern diets predispose individuals to deficiencies in one or more micronutrients. The present randomised, placebo-controlled, double-blind study investigated the cognitive, mood and fatigue reducing effects of taking a daily micronutrient supplement for 12 weeks. Ninety-six children received a supplement containing a selection of vitamins and minerals or matched placebo in the form of chewable tablets daily for 12 weeks. Cognitive performance was assessed using an internet-based battery and the Cognitive Drug Research (CDR) computerised battery. The internet battery included mood visual analogue scales. On the laboratory visits on the first (Day 1) and last (Day 85) days of treatment children completed both batteries pre-dose and at 1 and 3 h post-dose. During the interim period, on Day 29 and Day 57, they completed assessments at home under parental supervision using only the internet battery. Results showed that, compared to placebo, participants in the active group performed better on the attention tasks from the internet battery throughout the assessments, with this effect becoming apparent on the first day of treatment. Decrements on one task of memory after 12 weeks were detected. There were no significant changes on measures of mood or fatigue.