Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine

Spermidine and its derivative, hypusinated eIF5A, are essential for the growth of Saccharomyces cerevisiae. Very low concentrations of spermidine (10⁻⁸ M) are sufficient for the growth of S. cerevisiae polyamine auxotrophs (spe1Δ, spe2Δ, and spe3Δ). Under these conditions, even though the growth rat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-05, Vol.105 (18), p.6554-6559
Hauptverfasser:	Chattopadhyay, Manas K, Park, Myung Hee, Tabor, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Biochemistry Biological Sciences Biosynthesis Cell growth Cultured cells Eukaryotic Translation Initiation Factor 5A hypusinated eukaryotic initiation factor 5A hypusine Intracellular Space - drug effects Intracellular Space - metabolism Lysine - analogs & derivatives Lysine - metabolism microbial growth Microbiology Peptide initiation factors Peptide Initiation Factors - metabolism Polyamines Protein precursors Protein synthesis Proteins Radioactive decay RNA-Binding Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism spermidine Spermidine - analogs & derivatives Spermidine - metabolism Spermidine - pharmacology translation (genetics) Tritium Yeast Yeasts
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Zusammenfassung:	Spermidine and its derivative, hypusinated eIF5A, are essential for the growth of Saccharomyces cerevisiae. Very low concentrations of spermidine (10⁻⁸ M) are sufficient for the growth of S. cerevisiae polyamine auxotrophs (spe1Δ, spe2Δ, and spe3Δ). Under these conditions, even though the growth rate is near normal, the internal concentration of spermidine is
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0710970105