Evaluation of the Synergetic Effect of Water Soluble Extracts of Green Tea (Camellia sinensis) on the Activity of Ciprofloxacin in Urinary Isolated E. coli

The aim of this study is the evaluation of the synergistic effect of sub-MIC doses of ciprofloxacin with water soluble green tea extract against urinary tract isolates of E. coli. A total of 18 isolates were collected from urine specimens submitted to a clinical diagnostic Laboratory in Urmia, Iran. The amounts of MIC and MBC for green tea water extract, ciprofloxacin or a mixture of green tea with sub-MIC doses of ciprofloxacin were determined and three groups were compared. The Synergism between ciprofloxacin and water soluble green tea extracts were seen for 93.7% (15 of 16 tested) of bacterial isolates. This study suggests that combination of water soluble green tea extracts and ciprofloxacin has in vitro synergistic effect on urinary tract isolated E. coli.