Defining Neuropsychiatric Inventory scale differences across frontotemporal dementia syndromes

Aim The aim of this study was to assess the ability of Neuropsychiatric Inventory (NPI) scale profiles to differentiate between distinct frontotemporal dementia (FTD) subtypes. Methods The NPI was used to assess 311 older patients who had been clinically diagnosed with FTD. FTD subtypes included behavioural variant FTD (bvFTD, n = 121), primary progressive aphasia (semantic variant (n = 69), non‐fluent agrammatic variant (n = 31), and logopenic variant (n = 0)), FTD‐motor neuron disease (n = 4), progressive supranuclear palsy (n = 43), and corticobasal syndrome (n = 43). Total NPI score and scores for each NPI item were correlated across the distinct FTD subtypes. Results Patients with bvFTD showed significantly greater impairment on their total NPI score than patients with corticobasal syndrome (P