Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae

A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-03, Vol.70 (3), p.412-416
Hauptverfasser:	Wright, Amy E, Botelho, Julianne Cook, Guzmán, Esther, Harmody, Dedra, Linley, Patricia, McCarthy, Peter J, Pitts, Tara P, Pomponi, Shirley A, Reed, John K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Candida albicans Candida albicans - drug effects chemical analysis chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor General pharmacology Humans Inhibitory Concentration 50 Leukemia P388 macrolides Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Medical sciences mice Microbial Sensitivity Tests Molecular Structure Neopeltidae neopeltolide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry Porifera - classification spectral analysis stereochemistry Tumor Cells, Cultured
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Zusammenfassung:	A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np060597h