Hepatitis C Treatment for People With Severe Mental Illness

Over 4 million people in the United States are chronically infected with hepatitis C virus (HCV), and, if untreated, over 20% of these will progress to more serious disease. Persons with severe mental illness (SMI) have markedly elevated rates of HCV infection, but treatment of persons with SMI and...

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Veröffentlicht in:	Psychosomatics (Washington, D.C.) D.C.), 2006-03, Vol.47 (2), p.93-107
Hauptverfasser:	Mistler, Lisa A., Brunette, Mary F., Marsh, Bryan J., Vidaver, Robert M., Luckoor, Ravi, Rosenberg, Stanley D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - adverse effects Biological and medical sciences Depressive Disorder, Major - chemically induced Depressive Disorder, Major - epidemiology Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology Human viral diseases Humans Infectious diseases Interferons - adverse effects Medical sciences Mental Disorders - epidemiology Viral diseases Viral hepatitis
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Beschreibung
Zusammenfassung:	Over 4 million people in the United States are chronically infected with hepatitis C virus (HCV), and, if untreated, over 20% of these will progress to more serious disease. Persons with severe mental illness (SMI) have markedly elevated rates of HCV infection, but treatment of persons with SMI and HCV has been controversial. Effective antiviral treatment is available, but side effects include depression and other neuropsychiatric symptoms. This article reviews the available data on neuropsychiatric side effects of interferon (IFN) treatment, discusses the limitations of the current research, and makes recommendations regarding HCV treatment in persons with SMI
ISSN:	0033-3182 1545-7206
DOI:	10.1176/appi.psy.47.2.93