Muscanone: a 3- O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

A new antifungal flavanone, muscanone ( 1), was isolated along with known naringenin ( 2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were dete...

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Veröffentlicht in:	Phytochemistry (Oxford) 2003-04, Vol.62 (8), p.1251-1255
Hauptverfasser:	Fatope, Majekodunmi O., Al-Burtomani, Suad Khamis S., Ochei, John O., Abdulnour, Abdulrahman O., Al-Kindy, Salma M.Z., Takeda, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal activity Antifungal Agents - chemistry Antifungal Agents - pharmacology Artemia - drug effects Brine shrimp lethality test Burseraceae Candida albicans Candida albicans - drug effects Chemical Fractionation Commiphora - chemistry Commiphora wightii Flavanone Flavanones Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Microbial Sensitivity Tests Nuclear Magnetic Resonance, Biomolecular Spectrometry, Mass, Electrospray Ionization Structure elucidation Toxicity Tests - methods
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Zusammenfassung:	A new antifungal flavanone, muscanone ( 1), was isolated along with known naringenin ( 2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H– 1H COSY, HSQC and HMBC spectral data. Muscanone ( 1) was identified as 3- O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported. Muscanone ( 1) together with naringenin ( 2) have been isolated from the trunk of C. wightii. Muscanone inhibited the growth of Candida albicans at 250 μg/ml.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(02)00686-6