Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics

The ability to charge huge biomolecules without breaking them apart has made matrix-assisted laser desorption/ionization (MALDI) mass spectrometry an indispensable tool for biomolecular analysis. Conventional, empirically selected matrices produce abundant matrix ion clusters in the low-mass region...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-06, Vol.106 (25), p.10092-10096
Hauptverfasser:	Shroff, Rohit, Rulíšek, Lubomír, Doubský, Jan, Svatoš, Aleš
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyrthosiphon pisum Animals Aphids - chemistry Aphids - metabolism Arabidopsis - chemistry Arabidopsis - metabolism Arabidopsis thaliana Biosynthesis Chemical bases Desorption Drosophila melanogaster Drosophila melanogaster - chemistry Drosophila melanogaster - metabolism Fatty acids Flowers & plants Glucosinolates Humans Insects Ionization Ions Lasers Mass spectrometry Mass spectroscopy Metabolic Networks and Pathways Metabolomics Molecules Physical Sciences Short chain fatty acids Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Tissues
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Beschreibung
Zusammenfassung:	The ability to charge huge biomolecules without breaking them apart has made matrix-assisted laser desorption/ionization (MALDI) mass spectrometry an indispensable tool for biomolecular analysis. Conventional, empirically selected matrices produce abundant matrix ion clusters in the low-mass region (
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0900914106