Expression of DDB2 Protein in the Initiation, Progression, and Prognosis of Colorectal Cancer

Expression of DDB2 Protein in the Initiation, Progression, and Prognosis of Colorectal Cancer

Background Damage-specific DNA binding protein 2 (DDB2) is implicated in the recognition of DNA damage and the initiation of nucleotide excision repair process. The aim of this study was to explore the role of DDB2 in the initiation, progression, and prognosis of colorectal cancer (CRC). Methods Tot...

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Veröffentlicht in:Digestive diseases and sciences 2018-11, Vol.63 (11), p.2959-2968
Hauptverfasser: Yang, Huaiwei, Liu, Jingwei, Jing, Jingjing, Wang, Zeyang, Li, Yi, Gou, Kaihua, Feng, Xue, Yuan, Yuan, Xing, Chengzhong
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma - metabolism
Biochemistry
China - epidemiology
Colon - pathology
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Comparative analysis
Disease Progression
DNA damage
DNA-Binding Proteins - metabolism
Female
Gastroenterology
Genetic research
Health aspects
Hepatology
Humans
Immunohistochemistry
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Prognosis
Protein binding
Proteins
Rectum - pathology
Survival analysis
Transplant Surgery
Women
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Zusammenfassung:Background Damage-specific DNA binding protein 2 (DDB2) is implicated in the recognition of DNA damage and the initiation of nucleotide excision repair process. The aim of this study was to explore the role of DDB2 in the initiation, progression, and prognosis of colorectal cancer (CRC). Methods Totally tissues of 300 CRC and 300 adjacent, 267 colorectal adenoma (CRA) and 214 normal (NOR) were collected. The expression of DDB2 protein was detected by immunohistochemical staining. Results DDB2 protein was highly expressed in CRC and CRA compared with NOR ( P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-018-5224-z