Varicella zoster virus cerebral aneurysmal vasculopathy presenting in a newly-diagnosed HIV-positive patient

We report the case of a newly-diagnosed HIV-positive patient with varicella zoster virus aneurysmal vasculopathy confirmed on intrathecal antibody testing, despite a negative Cerebrospinal fluid (CSF) Varicella Zoster Virus (VZV) Polymerase Chain Reaction (PCR). This highlights the importance of pro...

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Veröffentlicht in:	International journal of STD & AIDS 2018-11, Vol.29 (13), p.1351-1353
Hauptverfasser:	Tomkins, Andrew, Babu, Chitra, Herwadkar, Amit, Siripurapu, Rekha, McKee, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Anti-Retroviral Agents - administration & dosage Antiviral Agents - administration & dosage Brain - blood supply Brain - diagnostic imaging Cerebral Arterial Diseases - diagnostic imaging Computed Tomography Angiography Encephalitis, Varicella Zoster - complications Encephalitis, Varicella Zoster - drug therapy Female Herpesvirus 3, Human - isolation & purification HIV Seropositivity - diagnosis HIV Seropositivity - drug therapy Humans Intracranial Aneurysm - diagnostic imaging Intracranial Hemorrhages - diagnostic imaging Intracranial Hemorrhages - etiology Intracranial Hemorrhages - virology Magnetic Resonance Imaging Prednisolone - administration & dosage Treatment Outcome Varicella Zoster Virus Infection - diagnosis Varicella Zoster Virus Infection - drug therapy
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Zusammenfassung:	We report the case of a newly-diagnosed HIV-positive patient with varicella zoster virus aneurysmal vasculopathy confirmed on intrathecal antibody testing, despite a negative Cerebrospinal fluid (CSF) Varicella Zoster Virus (VZV) Polymerase Chain Reaction (PCR). This highlights the importance of prompt treatment with antiviral and steroid therapy in the presence of clinical or radiological suspicion whilst awaiting further confirmatory testing.
ISSN:	0956-4624 1758-1052
DOI:	10.1177/0956462418786334